I build human joint organoid systems, map how environmental exposure damages cartilage, and develop regenerative repair strategies aimed at preventing — and reversing — osteoarthritis.
My work connects stem cell biology, inflammatory microenvironments, and targeted gene/cell therapy delivery in degenerating joints. I care about replacing “wait until surgery” with “protect and rebuild function before disability.” I believe joint failure is not an inevitable part of aging — it's an engineering and biology problem we can solve.
Core areas: osteoarthritis biology · exposure toxicology · stem-cell-derived joint organoids · multicellular inflammation models · targeted repair delivery.
Most patients are told to live with pain until joint replacement. That is a failure of imagination. We believe in catching the earliest inflammatory and structural changes — then actively repairing the joint using targeted, trackable, regulatory-path gene and cell therapy strategies.
These are not side projects or “future plans.” These are the real systems, assays, and translational concepts I am actively building and iterating.
I grow multicellular joint-like organoids from human stem cells, combining cartilage- and synovium-like compartments. This lets me track inflammatory crosstalk and cartilage breakdown in a controlled system.
These organoids are used to test early-stage regenerative interventions.I model pollutant exposure and biomechanical overload to see how “real world” joint stress triggers aggressive inflammatory cascades linked to early OA.
Goal: identify exposure signatures before irreversible structural damage.I explore focused delivery of pro-regenerative cells and engineered factors to resurface damaged cartilage, calm inflammation, and stabilize function.
Translation path: cell/gene payloads that can be regulated and tracked.I design everything with the end in mind: manufacturability, delivery in clinic, safety/readout, possible regulatory track.
The point is human benefit, not just cool biology.I post walkthroughs of new assays, early degeneration phenotypes, exposure models, and repair concepts. You see the pipeline as it's being built — not just the final figure in a PDF.
This is meant for other researchers, clinicians, and serious collaborators. Not general “biohacking,” not medical advice.
Here’s what I’m looking for:
Email a short intro. Include your field, the idea you want to test, and what resource you need (model system, assay capability, dataset, co-development).
Private area for registered collaborators. Access requires institutional affiliation and authenticated ORCID iD. Pre-publication data, draft protocols, and raw microscopy can be shared under NDA.